24.10.2012 Investigation of a Perilla frutescens special extract. Anti-inflammatory and immune-modulatory properties

Perilla frutescens (L.) Britton leaves are used as food and in traditional medicine. A Perilla leaf special extract was used to investigate the anti-inflammatory effects and mode of immune-modulatory properties in the following ex vivo experiments addressing different immune cells.

After stimulation, pattern of cytokines were determined and thus information about mode of action derived. As a result, anti-inflammatory effects were seen on the monocytic level with significant reduction of TNFα production whereas on the T-helper cellular level, reactions were less pronounced but a shift towards a TH2-helper response was identified. Both effects were dose dependent. Results underline the anti-inflammatory and other immune-modulatory properties which might impact the beneficial effects in different indications, like for example irritable bowel syndrome.

The paper is available here.

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