Aging is a dominant risk factor for cardiovascular disease. However, initial signs of cardiovascular risk factors can even be found in the young population.

Calorie restriction occurs to be one of the most promising strategy slowing down the process of aging and supporting cardiovascular health. It activates sirtuin 1, associated with energy metabolism, circulation, and longevity. Furthermore, sirtuin 1 triggers the enzyme endothelial nitric oxide synthase (eNOS) promoting the cardiovascular systems with nitric oxide (NO) is a potent vasodilator, anti-inflammatory, and antioxidant agent.

That’s why Vital Solutions' R&D team searched for natural ingredients that imitate the effect of calorie restriction without lowering food intake.

The innovation is: Careless - an exclusive mango fruit preparation, Mangifera indica (L.), which mimics calorie restriction. It helps you to care less about circulation, metabolism and aging while delivering the great taste and pleasure of exotic mango fruits.

Careless was divided into two products, Careflow and Care300, based on applications.

Careflow - activities sirtuin 1 and eNOS by mimicking calorie restriction. It supports your cardiovascular capacity and reduces the risk to develop cardiovascular disease (CVD), while delivering the great taste and pleasure of exotic mango fruits.

Careflow guarantees highest, consistent and defined quality. It is scientifically proven, IP protected, and frequently used in food supplements.

Careflow® helps to support:*

  • Microcirulation
  • Healthy blood pressure
  • Metabolism & Energy

Human study results confirm:

Careflow is able to stimulate microcirculation. In a pilot study as well as a long term double blind, randomized, placebo-controlled, parallel design human study with 50 healthy people, 100 mg Careless were administered once a day. Results demonstrated that Careflow is able to support microcirculation and heathy blood pressure.

Products featuring this Ingredient


Appearance: Fine yellow powder with characteristic odor
Loss on drying: < 5.0 %
Solubility Not soluble in water, dispersible in water
Particle size: > 95 % < 160 µm
Bulk density: 0.4 - 0.6 g/ml
Tapped density: 0.5 - 0.7 g/ml
Mangiferin ≥ 0.03 %
pH 3.1 - 4.8 10 % water solution
Foreign matter not detected
Pesticides (EC) No 396/2005: complies
Heavy metals (EC) No 1881/2006: complies
Microbiology: Ph. Eur. 7ed Cat. 5.1.4 complies


Careflow® - Science & Application

Careflow, the proprietary Mangifera indica fruit preparation, is a 100% pure mango fruit powder – validated for efficacy.

In vitro and human studies demonstrated that Careflow activates key metabolic enzymes, SIRT1 and eNOS, which support circulation and endothelial function.

Careflow is a high quality, sustainable, IP protected, natural ingredient, approved to be used in food supplements, foods and beverages. It is a water dispersible fine beige powder with a fruity taste. Its recommended daily dosage is 100 mg.

Careflow® - Origin & Production

Careflow is a 100% pure mango fruit powder, obtained from a variety called "Kili-mookku”. The carefully selected fruits are organically cultivated in the South of India in the Tamil Nadu region and harvested at the special degree of ripeness, when the content of secondary plant ingredients is high and sugar is low. Eating fresh ripe mangoes may not provide the same health effects.

Vital Solutions' research and extensive know-how in natural products enabled them to identify this special subspecies supporting healthy metabolic aging.

Careflow’s modern, state of the art and GMP compliant production facility ensures reproducible quality of the product. All processing steps are organic certified. Careless complies with highest quality and traceability standards, completed by phytochemical characterization and stability data. Careflow is made in Germany.



Careflow® supports concepts for:*


Cardiovascular health
- to improve microcirculation & healthy blood pressure

- to improve mitochondrial biogenesis & physical energy

Sports nutrition
- to support oxygen supply & endurance


* These statements have not been evaluated by FDA and EFSA. The product is not intended to diagnose, treat or cure any disease.