Aging is a dominant risk factor for cardiovascular disease. However, initial signs of cardiovascular risk factors can even be found in the young population.

Careflow activates the enzyme endothelial nitric oxide synthase (eNOS), releasing nitric oxide (NO), which is a potent vasodilator, anti-inflammatory, and antioxidant agent. It is scientifically proven, IP protected, and approved to be used in food supplements, foods and beverages.

In vitro and human studies demonstrated that Careflow improves microcirculation, physical powder and a healthy heart.

Careflow® helps to support:*

    • Microcirculation
    • Metabolism and Energy
    • Healthy heart

Human study results confirm:

Careflow is able to stimulate microcirculation. In a pilot study as well as a long term double blind, randomized, placebo-controlled, parallel design human study with 50 healthy people, 100 mg Careless were administered once a day. Results demonstrated that Careflow is able to support microcirculation and healthy blood pressure.

Products featuring Careflow®

Planta Medica front page

In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation
Gerstgrasser et al. Planta Med 2016; 82(04): 298-304

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Planta Medica front page

Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers
Buchwald-Werner et al. Planta Med DOI: 10.1055/s-0043-103017

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Appearance. Fine, yellow powder with characteristic odor
Loss on drying < 5.0 %
Solubility Not soluble in water, dispersible in water
Particle size > 95 % < 160 µm
Bulk density 0.4 - 0.6 g/ml
Tapped density 0.5 - 0.7 g/ml
Mangiferin ≥ 0.03 %
pH 3.1 - 4.8 10 % water solution
Foreign matter not detected
Pesticides (EC) No 396/2005 complies
Heavy metals (EC) No 1881/2006 complies
Microbiology: Ph. Eur.7 ed Cat. 5.1.4 complies

Careflow® – Science & Application

Careflow, the proprietary Mangifera indica fruit preparation, is a 100% pure mango fruit powder – validated for efficacy. In vitro and human studies demonstrated that Careflow activates key metabolic enzymes, SIRT1 and eNOS, which support circulation and endothelial function.

Careflow is a high quality, sustainable, IP protected, natural ingredient, approved to be used in food supplements, foods and beverages. It is a water dispersible fine beige powder with a fruity taste.
Its recommended daily dosage is 100 mg.

Careflow® – Origin & Production

Careflow is a 100% pure mango fruit powder, obtained from a variety called „Kili-mookku”. The carefully selected fruits are organically cultivated in the South of India in the Tamil Nadu region and harvested at the special degree of ripeness, when the content of secondary plant ingredients is high and sugar is low. Eating fresh ripe mangoes may not provide the same health effects.

Vital Solutions‘ research and extensive know-how in natural products enabled them to identify this special subspecies supporting healthy metabolic aging. Careflow’s modern, state of the art and GMP compliant production facility ensures reproducible quality of the product. All processing steps are organic certified. Careflow complies with highest quality and traceability standards, completed by phytochemical characterization and stability data. Careflow is made in Germany.

Careflow Signature Picture Cell and blood vessel

Careflow® supports concepts for:*

Sports nutrition
– to support oxygen supply & endurance

Beauty inside
– to improve mitochondrial biogenesis & skin glow

Cardiovascular health
– to improve microcirculation & healthy blood pressure

Men’s health
– to improve blood flow and performance by antioxidative effects


* These statements have not been evaluated by FDA and EFSA.
The product is not intended to diagnose, treat or cure any disease.