Mango (Mangifera indica L.) is not only a delicious fruit but also known for its nutritional value. The fruits contain significant levels of bioactive compounds including polyphenols and vitamins. Careless®, a special Mangifera indica L. fruit powder, was used to investigate the activation of master regulators of the aging process such as sirtuin 1 and AMP activated protein kinase.
Furthermore, related effects like mitochondrial biogenesis as well as anti-oxidative effects based on superoxide dismutase activity augmentation were investigated. As a result, the special Mangifera indica L. fruit powder showed activation of these master regulators and related modulation underlining potential beneficial effects for well aging. This paper summarizes the in vitro investigation of Careless®.
The peer-reviewed full text paper is available here.