Calorie restriction occurs to be one of the most promising strategy slowing down the process of aging and supporting health. Careless activates enzymes, especially sirtuin 1, associated with energy metabolism, stress resistance, cell survival, and longevity.

That’s why Vital Solutions‘ R&D team searched for natural ingredients that imitate the effect of calorie restriction without lowering food intake.

The innovation is: Careless – an exclusive mango fruit preparation, Mangifera indica (L.), which mimics calorie restriction and helps you care less about metabolism and aging while delivering the great taste and pleasure of exotic mango fruits. Careless guarantees highest, consistent and defined quality. It is scientifically proven, IP protected, and frequently used in food supplements.
You want to learn more about Careless? Have a look at this video.

Careless® helps to support:*

    • Metabolism & Energy
    • Glucose tolerance
    • Microcirulation
    • Healthy blood pressure

Human study results confirm:

Careless is able to stimulate metabolism and circulation. In an acut pilot study as well as in a long term double blind, randomized, placebo-controlled, parallel design human study with 75 healthy people, 100 mg or 300 mg Careless were administered once a day. Results demonstrated that Careless is able to support microcirculation, healthy blood pressure and glucose tolerance.
Careless was divided into two products, Careflow and Care300, based on applications.

Related scientific publications

Planta Medica front page

In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation

Gerstgrasser et al. Planta Med 2016; 82(04): 298-304

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Planta Medica front page

Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers

Buchwald-Werner et al. Planta Med DOI: 10.1055/s-0043-103017

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Appearance Fine yellow powder with characteristic odor
Loss on drying < 5.0 %
Solubility Not soluble in water, dispersible in water
Particle size > 95 % < 160 µm
Bulk density 0.4 - 0.6 g/ml
Tapped density 0.5 - 0.7 g/ml
pH 3.1 - 4.8 10 % water solution
Foreign matter not detected
Pesticides (EC) No 396/2005 complies
Heavy metals (EC) No 1881/2006 complies
Microbiology: Ph. Eur. 7ed Cat. 5.1.4 complies


Careless® – Science & Application

Careless, the proprietary Mangifera indica fruit preparation, is a 100% pure mango fruit powder – validated for efficacy.

In vitro and human studies demonstrated that Careless activates key metabolic master switch enzymes, AMPK and SIRT1, which regulate energy homeostasis, and thereby stimulates metabolism and circulation.

Careless is a high quality, sustainable, IP protected, natural ingredient, approved to be used in food supplements, foods and beverages. It is a water dispersible fine beige powder with a fruity taste. It’s recommended daily dosage is 100 – 300 mg, depending on application.


Careless® – Origin & Production

Careless is a 100% pure mango fruit powder, obtained from a variety called Kili-mookku”. The carefully selected fruits are organically cultivated in the South of India in the Tamil Nadu region and harvested at the special degree of ripeness, when the content of secondary plant ingredients is high and sugar is low. Eating fresh ripe mangoes may not provide the same health effects.

Vital Solutions‘ research and extensive know-how in natural products enabled them to identify this special subspecies supporting healthy metabolic aging.

Careless’s modern, state of the art,  GMP compliant production facility ensures reproducible quality of the product. All processing steps are organic certified. Careless complies with highest quality and traceability standards, completed by phytochemical characterization and stability data. Careless is made in Germany.

Careless Signature Picture Cell and blood vessel

Careless® supports concepts for:*

Metabolic health
– to improve glucose tolerance

Cardiovascular health
– to improve microcirculation & healthy blood pressure

Body composition
– to maintain a healthy body composition

– to improve mitochondrial biogenesis & physical energy

Sports nutrition
– to support oxygen supply & endurance

* These statements have not been evaluated by FDA and EFSA. The product is not intended to diagnose, treat or cure any disease.